Heparin-bonded expanded polytetrafluoroethylene femoropopliteal bypass grafts outperform expanded polytetrafluoroethylene grafts without heparin in a long-term comparison

Samson et al. 20161

Sarasota Vascular Specialists in Sarasota, Florida, USA

Primary patency of GORE® PROPATEN® Vascular Graft

N=87
1 year 92%
2 years 85%
3 years 85%
4 years 85%
5 years 85%

Patient characteristics*

Characteristic N %
Gangrene 27 20%
Ulceration 39 30%
Rest pain 40 30%
Claudication 43 33%
Runoff vessels  
0 2 2%
1 44 37%
2 49 41%
3 24 20%
Hypertension 110 84%
Diabetes 59 45%
Smoking 42 32%

Study details

  • Retrospective, non-randomized, single-center review of prospectively collected data
  • No adjunctive technique (patches or cuffs) were used
  • Most grafts were 6 mm ring reinforced
  • Clopidogrel usage had a significant benefit on overall primary patency
  • Loss of patency was found to be related to younger age, absence of claudication, isolated popliteal artery, and lower post-operative ABI
  • As early as 3 months, a significant difference in patency favoring GORE® PROPATEN® Vascular Graft was seen and was maintained at 5 years (74.5% vs 56.2%), and in both AK (85.2% vs 59.3%) and BK (59.6% vs 0.0%/undeterminable) locations

These data show that the [GORE® PROPATEN® Vascular Graft]  offered significantly better long-term patency over the SePTFE graft, suggesting [GORE® PROPATEN® Vascular Graft] as the prosthetic graft of choice for bypasses to the femoropopliteal artery when autologous vein is unavailable or inappropriate. — RH Samson

[GORE® PROPATEN® Vascular Grafts] seem to be as effective as vein for AK femoropopliteal artery bypass. Because of the excellent results observed in this series, we now use the [GORE® PROPATEN® Vascular Graft] preferentially over great saphenous vein for AK bypass except in younger patients with available appropriate autologous conduit. — RH Samson

* GORE® PROPATEN® Vascular Graft group

1. Samson RH, Morales R, Showalter DP, Lepore MR, Nair DG.  Heparin-bonded expanded polytetrafluoroethylene femoropopliteal bypass grafts outperform expanded polytetrafluoroethylene grafts without heparin in a long-term comparison.  Journal of Vascular Surgery 2016;64(3):638-647.

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