Patient Information > Treatments

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• Treating symptoms of portal hypertension
• TIPS procedure for treating portal hypertension
• What to expect during the TIPS procedure
• What to expect following a TIPS procedure
• Are there any risks associated with TIPS ?

Treating symptoms of portal hypertension

Many of the treatments for portal hypertension focus on managing symptoms. For patients who have cirrhosis and complications of portal hypertension, medication, lifestyle modifications and a specialized diet may be used to help manage the condition. For diet modification, a low salt or restricted protein diet may be recommended and patients may be referred to a dietician for advice on what foods to avoid, including alcohol avoidance.

Paracentesis, endoscopic band ligation (EBL) and TIPS may also be a part of the treatment.

Treating Ascites

Diuretics are often prescribed to reduce fluid retention. Sometimes medication alone is not sufficient, or a patient cannot tolerate diuretics. In these situations, large-volume paracenteses (LVP) may be needed to treat the ascites. LVP involves using an ultrasound-guided needle to drain the abdomen of fluid buildup. The fluid removed will be examined for signs of infection and to help determine if the fluid is caused by portal hypertension.

Some patients with portal hypertension develop refractory ascites, where ascites does not respond to diuretics or recurs shortly after LVP. Patients with refractory ascites typically require frequent paracentesis procedures.

Risks associated with LVP

In general, the development of ascites indicates advanced liver disease and patients may be referred for a liver transplant. Even in those circumstances, LVP may continue while waiting for a transplant. LVP can be costly,² time consuming and may be accompanied with one or more risks.

Potential risks associated with LVP can include, but are not limited to^3-6:

• Leaking of fluid at insertion site
• Bleeding at insertion site and internally
• Infection
• Electrolyte imbalance
• Bowel perforation
• Paracentesis-induced circulatory dysfunction
• Kidney injury

Treating variceal bleeding

Variceal bleeding is one of the most significant complications of varices resulting from portal hypertension. Varices are enlarged veins, often around the stomach and esophagus, and can be treated in a number of ways. Currently, the two most widely used treatments to prevent and treat esophageal variceal bleeding are medication (non-selective beta-blockers [NSBB]) and a minimally invasive procedure called variceal band ligation (VBL) or EBL. It is common that EBL is repeated when bleeding episodes recur. Gastric varices are located on the stomach, and are often considered a medical emergency when they bleed. Patients with gastric variceal bleeding are often treated with intravenous antibiotics, vasoactive medications and may undergo a minimally invasive procedure where a glue or tissue adhesive is injected at the site of the bleed. If those measures are unable to stop the bleeding, rescue measures, such as balloon tamponade, balloon-occluded retrograde transvenous obliteration (BRTO), TIPS or surgery may be required.

Risks associated with variceal bleeding

Every episode of variceal bleeding increases the patient's risk of morbidity and mortality. Complications of variceal bleeding may be due to the bleeding episode itself or related to procedures used to treat bleeding episodes. These complications may include, but are not limited to^7-9:

• Infection
• Hypotension and circulatory shock
• Hepatic encephalopathy
• Aspiration pneumonia
• Ulcers
• Esophageal perforation
• Death

The treatments to prevent bleeding are themselves not without risk. Although rare, adverse events from EBL can include perforation of the esophagus and ulcer-related bleeding.¹⁰ Beta blocker medications, often prescribed to help lower blood pressure, can cause side-effects like fatigue, sexual dysfunction, weight gain, shortness of breath, low blood pressure and nausea.

TIPS procedure for treating portal hypertension

If other treatments for ascites or variceal bleeding are not effective, then a TIPS procedure may be an appropriate therapy. While EBL and LVP treat the complications of portal hypertension, TIPS reduces portal hypertension, which is the underlying cause of the complications. Recent clinical evidence shows that many patients with portal hypertension experience higher survival and freedom from complications by undergoing TIPS earlier.¹¹

But what is a TIPS procedure? A TIPS procedure creates a new channel to route blood flow through the damaged liver and into the main blood vessels that lead blood back to the heart. A TIPS stent placed inside this channel allows a portion of blood to bypass the liver, reducing portal hypertension and its complications.¹²

The TIPS procedure is a minimally invasive procedure, typically requiring a short hospitalization. TIPS reduces portal hypertension, so alternative treatments such as medications, paracentesis for ascites and the treatment of varices may be needed less frequently or not at all.

What to expect during the TIPS procedure

There are specific medical guidance on what to expect when having a TIPS procedure. Generally, the procedure is performed in a hospital under sedation or general anesthesia by specially trained doctors called interventional radiologists. The procedure typically takes two to three hours, but may take longer. Direction about limiting food intake and medications before the procedure should be given to the patient. During the TIPS procedure, the patient will be connected to monitors to track heart rate and blood pressure and an intravenous line to administer medications.

The doctor uses X-ray pictures and X-ray dye (also called contrast dye) to guide the procedure. A needle is guided through the introducer sheath to the hepatic vein. Using X-ray guidance, the needle is directed from the hepatic vein into the portal vein, creating a tunnel between the hepatic and portal veins. A special balloon is used to enlarge the liver tunnel, and the doctor inserts the TIPS stent into the tunnel to help it remain open and allow blood flow (see Figure 1).

What to expect following a TIPS procedure

The TIPS procedure typically requires a hospital stay of one or more days, but could be longer.¹² During your hospital stay, the doctor will monitor the patients' health and may conduct additional tests. Once home, a specialized diet may be suggested and medications may be prescribed to manage the treatment. It is important to follow your physician’s recommendation for monitoring the TIPS stent and your health. Often a series of post-procedure check-ups will be scheduled at one month and six months and the doctor may recommend additional check-ups. The follow-up exams may consist of routine X-rays, an ultrasound and blood tests.

It is advisable to have a good support system available to participate in the post-TIPS care to help with diet, medication, doctor’s appointments and to generally monitor the condition for any warning signs.

Are there any risks associated with TIPS ?

All surgical procedures have risks. Some potential risks associated with a TIPS procedure can include, but are not limited to¹³:

• Fever
• Stiffness, bruising or soreness in the neck
• Reactions to medicines or dye
• Hepatic encephalopathy
• Damage to blood vessels
• Heart problems or abnormal heart rhythms
• Infection

Recent studies^11,14-16 indicate that for some patients, there is no increase of hepatic encephalopathy with TIPS when compared to standard treatments.

There may be additional risks that are not mentioned here. It is advised that the patient speaks with his doctor about any concerns or risks, complications you experience, and proper post-procedure treatment.